Major advances in software technologies will be required to enable the "new Internet." Areas of investigation will include large-scale, ad hoc wireless networks, a secure metacomputing infrastructure, mobile agent technologies, sensor simulation, sensor network integration, and development of new middleware and human-computer interfaces. The need for innovation in algorithms to match the vast size and complexity of this new Internet, in turn, indicates that mathematical research will also play a critically important role in our institute. UCSD will take the lead in this layer with strong collaboration from UCI's Information and Computer Science Department, Center for Networks and Middleware Information Systems, and Center of Integrated Information Technologies for Infrastructure Systems. Underlying all Calit2 software infrastructure development will be the need for security and scalability.

• Biomedical Informatics Research Network [BIRN]
• Citizen Awareness System for Crisis Mitigation [CAMAS]
• Collaborative Center for Internet Epidemiology and Defenses [CCIED]
• Community Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis [CAMERA]
• Disaster Portal
• Distributed Image and Information Processing for Automated Monitoring [Smart Vivarium]
• OptIPuter
• Real-time Observatories, Applications, and Data Management Network [ROADNet]
• Reconfigurable Ubiquitous Networked Embedded Systems [RUNES]
• Responding to Crises and Unexpected Events [RESCUE]
• ResponSphere
• Wireless Internet Information System for Medical Response in Disasters [WIISARD]